Application of Medical Ozone Therapy in Patients with Sickle Cell Anemia, Preliminary Report
DT: Nov 1989
AU: Silvia Menendez, Edgardo Espinosa, James A. Caplan and
Wilfredo Diaz
SO: National Center for Scientific Research, Ozone Research
Center, Havana, Cuba.
AB: In patients with sickle cell anemia, the reduction in the
availability of oxygen to the cells, produces painful
crisis, infarction, abdominal and/or muscle pains, ulcer,
etc. On the basis of some medical properties of ozone,
concerning the ability to increase the rate and the capacity
of absorption of oxygen in erythrocytes, and evaluation
about the effectiveness of this treatment for the prevention
and/or the timely resolution of the crisis was made. For
the controlled clinical trial, 55 adult sickle cell anemia
patients were studied, each suffering from painful crisis.
Two groups were established: control group, comprised of 25
patients who received conventional treatment, and
ozone/oxygen treated group, comprising 30 patients who
received the same treatment plus ozone therapy, by
intrarectal administration, during 15 sessions. The average
time required for resolution of painful sickle cell crisis
in ozone/oxygen treated patients was half the number of
hours required to solve painful crisis in control patients.
Frequency and severity of painful crisis in sickle cell
anemia patients who received ongoing ozone/oxygen therapy
diminished in the six-month-period-follow-up, in comparison
with control group patients.