Complex Use of Ozone for an Anaerobic Infection Control in Burnt Patients
18-8-2006
Struchkov A.A., Peretyagin S.P., Corotkova N.L., Vilkov S.A., Pylaeva S.L. and Kuvakina N.A. (Russia)
The presence of anaerobic infection in patients with large areas of thermal lesion
influences significantly against the burn disease evolution, as well as increases
lethality, achieving 56 % in clostridium infection and 48 - 60 % in non clostridium
form. Eight patients have been treated in the Russian Burn Center for the last 5 years,
in which a trauma was complicated with an anaerobic infection with the expressed clinical
manifestations and a critical intoxication. In 6 patients a sepsis was diagnosed, supported
by the laboratory investigations, in two cases a non clostridium infection was revealed
in a blood test. Ozone was used for the control of the anaerobic infection. Major
autohemotherapy (10 sessions) with an ozone dose of 500 - 1000 µg was applied under a
blood chemoluminescence control. The damaged extremities were irrigated with ozone-oxygen
mixture, using plastic bags, with an ozone concentration of 10 mg/L and a 60 min exposure
locally after a surgical treatment. Besides, the injured surface was irrigated with ozonized
physiologic saline solution at an ozone concentration of 3 mg/L. A sanction of disinfection
of premises by ozone with a concentration, exceeding an admissible concentration limit, was
concluded twice a day by 45 min in the individual isolated ward for the hospital infection
control. A patient’s respiration during a session of sanitation was provided through an
oxygen mask. The general state of these patients was improved after 2-3 days of treatments,
also the concentrations of creatinine, urea, myoglobin titer in blood were decreased, the
tissue edema was significantly decreased, the wound bacterial dissemination was 2 - 4 times
decreased. The sensibility of microflora to antibiotics was 3 - 5 times increased.