Decrease of blood cholesterol and stimulation of antioxidative
response in cardiopathy patients treated with endovenous ozone
therapy
Hernández F (1); Menéndez S (1); Wong R (2)
(1) Ozone Research Center, National Center for Scientific Research, Havana, Cuba.
(2) Medical and Surgical Research Center, National Center for Scientific Research, Havana, Cuba
Free Radic Biol Med, 19: 1, 1995 Jul, 115-9
Abstract
Patients with cardiac infarction show a decrease in glutathione
peroxidase and superoxide dismutase activities, which are
beginners in the scavenger processes of lipid peroxide and
superoxide radicals, respectively. In this study, we investigate
the effects of endovenous ozone therapy on serum lipid pattern and
on antioxidant defense system, such as te glutathione redox one,
in the blood of patients with myocardial infarct. Twenty-two
patients who had an infarction, between 3 months and 1 year before
the study, were treated with ozone by autohemotherapy during 15
sessions. A statistically significant decrease in plasma total
cholesterol and low density lipoprotein was observed. High
biologically significant increases on erythrocyte glutathione
peroxidase and glucose 6-phosphate dehydrogenase activities were
found. There was no change in plasma lipid peroxidation level. It
was concluded that endovenous ozone therapy in patients with
myocardial infarction has a beneficial effect on blood lipid
metabolism, provoking the activation of antioxidant protection
system.