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Effects of Ozone Treatment on the Infectivity of Hepatitis A Virus

UI - 91059292
AU - Vaughn JM
AU - Chen YS
AU - Novotny JF
AU - Strout D
AD - Department of Microbiology, University of New England College of Medicine, Biddeford, ME 04005.

AB - The inactivation of a large-focus-forming variant of hepatitis A virus (HM-175) by ozone was investigated. Experiments using mainly single-particle virus preparations suspended in phosphate-carbonate buffer were conducted over a range of pH levels (6-8) at 4 degrees C. Viral enumerations involved the use of a radioimmunofocus assay. While some tolerance to lower (i.e., 0.1-0.5 mg/L) ozone residuals was noted, the exposure of virus particles to ozone concentrations of 1 mg/L or greater at all pH levels resulted in their complete (5 log) inactivation within 60 s. The pH-related effects that were observed were not considered to be significant.

PT - JOURNAL ARTICLE
LA - Eng
SO - Can J Microbiol 1990 Aug;36(8):557-60



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