Influence Of Ozone Therapy On Cellular Immunity In Disseminated Sclerosis Patients
Claudia Kontorshchikova, O. Kukarina, A. Lebedeva and S. Kotov.
Medical Academy, Nizhny Novgorod, Russia.
This work represents the results of immunologic status investigations in patients with disseminated sclerosis in response to ozone therapy, by comparison with a control group. The data were estimated by application a monoclonal antibodies (MCA) panel: LT4 (CD4 ), LT-DR ( HLA - DR ), LT22 (CD22), LT8 ( CD8), LT3 ( CD3 ). The ozone therapy treatment consisted of 5-6 infusions - every other day - of an ozonized isotonic solution with ozone concentration being 290- 35- mcg/L of physiological saline solution. Before the treatment of ozone therapy, the patients with disseminated sclerosis had, in difference to healthy persons, increase figures of CD22 in 100 % of cases, increase in CD8 in 60 % (in 40 % the data were in the normal range), decrease of CD4 in 70 %. These changes are inherent characteristics of autoimmune pathology, as disseminated sclerosis is. After the ozone therapy, CD22 increased in 60 % of cases, though in 40 %, CD22 decreased to the normal levels, and this phenomen is due to individual reactions toward ozone therapy. CD8 increased in 100 % of cases, whereas CD4 regained the normal values in 70 % of patients. One month after finished the ozone therapy, all the indices returned to their original levels. Both normalization of CD4 levels and activation of cellular immunity processes proved the validity of the inclusion of ozone therapy into the comprehensive treatment of disseminated sclerosis and, furthermore, the need for repeated courses of ozone therapy.
Source: 3rd International Symposia on Ozone Applications, June 2000.