Inhibition Of Interleukin-8 Synthesis By Intraarticular Oxygen/Ozone Therapy In Patients With Rheumatoid Arthritis

Z. Fahmy

Augusta Klinik, Bad Kreuznach, Germany.

5 patients with definite rheumatoid arthritis and knee effusions under constant doses of NSARD therapy were treated with up to 6 intraarticular (i.a.) injections every 3 to 7 days. Ar oxygen/ozone matched randomized control group who received a single i.a.injection of 40 mg triamcinolone hexatonide (TC) was monitored according to the same protocol. The intraarticular granulocyte counts and IL-8 levels decreases in oxygen/ozone treated patients on day 10-13 and stayes low in those patients who could be re-evaluated after 13 weeks. Compared to the IL-8 levels, the other tested cytokine levels showed only minor changes on day 10-13. There was no need for a re-injection in the TC group during 13 weeks study phase. We conclude that intraarticular oxygen/ozone therapy results in a decrease of SF-granulocyte counts. This effect may be due to the impairment of IL-8 mediated chemotaxis by decreased IL-8 synthesis in synovial fluid mononuclear cells. Clinically, repeated intraarticular oxygen/ozone therapy results in a worse 13 week outcome than i.a.steroid treatment measured in an intention-to-treat analysis.

Source: 3rd International Symposia on Ozone Applications, June 2000.