Medical Ozone in the Treatment of lower Extremities Peripheral
S.N. Gorbunov, N.A. Mironov, S.P. Alyokhina, G.M. Pikalova
Nizhegorodski Reginal Hospital of War Veterans
Ozon Therapy Center
Atherosclerotic vessels disorders of the lower extremities are the
most common pathology in advanced age groups of patients. It is
considered to be one of the "civiliration discase" manifestations
that lead to non-healing trophic ulcers and even to gangrene of
extremities, that might cause invalidism and in some cases results in
fatal outcomes. The common treatment to prevent atherosclerotic
disorders and the use of vasodilators do not prove to be effective.
Surgical interventions into vegetative nervous system provide a rare
steady clinical effect either.
We have observed 132 patients in the age group of 62-84, all of them
being war invalids with III-IV grade peripheral circulation disorder
in lower extremities. All the patients had intermittent
clandication, shorting of walking distance down to 150-200 m, cooling
in the extremities and pains in calf muscles (musculus
gastrocnemius), 31 patients had circulation disorders complicated by
trophic ulcers the size of which being in the range of 5-32 sg. cm
and duration in the range of 2-18 years.
11 patients had crus and femur wounds of 47-50 years standing.
Anamnesis of 8 patients indicated frostbite episodes during the war.
All the patients had repeatedly received traditional medical
treatment before ozone therapy was administered, 3 patients having
had unilateral and bilateral sympathectomy. It should be noted that
while ozonetherapy was administered to all the patients, its methods
The first group of patients received 8-10 intravenous injections of
ozonesaturated rheopolyglucin solutions (rheamacrodex) in the dosage
of 400,0 ml.
In the second group of patients intravenous ozone administration was
combined with subcutaneous injections of gaseous ozone.
The third group of patients in addition to the first tow methods of
ozone introduction received 3-4 seance of major ozone autohematherapy
Patients with trophical ulcers were administered external ozonization
in plastic bags. By the end of the treatment course all the patients
noted significant improvement of their well-being with clinical
evidence of the lack of pains or cramps in calf muscles and warming
of the extremities. There was also noted a 10-15 fold increase in
the walking distance. The combined ozonetherapy provided the most
rapid clinical improvement. There increased blood saturation with
oxygen and its voltage in vascular bed (channel) and tissues. In all
the cases the ulcerous surface epitalization rate was up to 2-4 sq.
cm a day. In two patients ozonated vulvosorbtion was done to
stimulate the epitalization process. Surgical intervention was not
needed for the heavy of trophic ulcers. The received data prove
complex ozonetherapy to be highly effective in the treatment of lower
extremities peripheral circulation disorders in the patients of the
advanced age group.