Ozone Influence On The Level Of Endotoxicosis In General Hyperthermia Condition Of Oncologic Patients
G.Boyarinov; M.Goryachev; Y.Brichin; N.Skachov; N.Smirnova; B.Shubin;
M.Chusova; A.Ermolaeva and T.Rumyantseva.
Military Medical Institute of the Federal Border Guard Service of Russia,
Regional Oncologic Center, Nizhni Novgorod, Russia.
At present time, general hyperthermia is more frequently used as a
chemotherapy modification for oncologic disease treatment. The sessions
consist in intravenous infusion of the chemopreparations at the temperature
of 40.5 - 410C, general anesthesia and craniocerebral hyperthermia. This
method is used in inoperable, and low sensitivity to radiation, and
chemotherapy patients.
27 patients with cancer in different locations were divided in two groups:
control - 15 patients and with ozone therapy - 12 patients. All patients had
II-III stage of endotoxicosis. For detoxification, patients of the
investigated group received ozone therapy before the general hyperthermia in
the form of intravenous infusion of ozonated physiological solution with an
ozone concentration of 3 mg/L.
After ozone therapy a significant decrease of endotoxicosis was observed.
Besides this, the general health state improved. After general hyperthermia,
the degree of endotoxicosis and general health state were determined in both
groups. Thus, using ozone therapy as a method of oxidative detoxification,
it is possible to significantly decrease the degree of endotoxicosis in
oncologic patients at a general hyperthermia conduction.