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Ozone Therapy In Different Ophthalmologic Diseases

E. C. Díaz, L.Borrego, S. Menéndez, L. R. Borrego, R. A. Borrego

Provincial Center of Retinosis Pigmentaria, Holguin, Cuba.
Ozone Research Center, Cuba.

Since 1992, we have been using ozone therapy in our province, a new therapeutic option in the treatment of Retitiitis Pigmentosa. Taking into account the different medical properties of ozone such as: improvement of the oxygen transportation to tissue; activation of the enzymes participating in peroxide or oxygen radical scavenging; immunological and metabolic modulation; as well as an easily applied therapy with no side effects, we decided to use ozone therapy in other ophthalmologic diseases. 180 patients were treated with daily rectal ozone therapy, for 20 days, of which 80 had retinitis pigmentosa (not systemic, stage I and II), 45 had progressive myopia, 25 had chronic glaucoma of open angle (tonometrically compensated), 20 had optic atrophy (less than one year of evolution), and 10 had diabetic retinopathy (not proliferative). Healing criteria was according to each disease.

Clinical evaluation was made every 3 months, up to 1 year. In patients with retinitis pigmentosa, 75 % improved their visual acuity (post-treatment and 6 months later). After 1 year, 23 % of the improvement still remained. 76 % of the patients improved their visual field after treatment and up to 9 months, but after 1 year, 16 % lost their improvement. With respect to progressive myopia, visual acuity increased in 78 % (post-treatment and 9 months later) and remained in 58 % after 1 year. In glaucoma, 65% increased their visual acuity (post-treatment and 9 months later), and 53% maintained improvement after 1 year. Visual field increased in 76 % of patients, post-treatment and after 1 year. In diabetic retinopathy, 60 % improved their visual acuity (post-treatment), diminishing to 40 %, 6 months later and 20 %, after 1 year.

With respect to optic atrophy, 45 % of improvement in visual field was achieved (post-treatment) maintaining its figure after 1 year. It is therefore concluded that ozone therapy offers very good results in these opthalmologic diseases, without side effects, repeat treatment being necessary, depending on the disease and the patient's condition.

Source: 2nd International Symposium on Ozone Applications Havana, Cuba - Mach 24-26, 1997.

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